RAF Typhoon FGR4s have conducted a mission with French warplanes in a combined operation against an hidden munitions depot in Syria employed by the IS group, as stated by the UK's MoD.
The site, located using surveillance, was thought to be storing arms and explosives, the release indicated, and was located in mountains just to the north of the ancient city of Palmyra in the heart of Syria.
"The RAF jets utilized precision-guided Paveway IV munitions to hit a number of approach shafts leading to the facility... initial indications suggest the objective was successfully hit," officials stated.
There was no indication of any civilian casualties in the strike conducted Saturday night and all the aircraft made a safe return, the defence officials confirmed.
The Typhoon fighters were supported by a Voyager tanker plane.
Daesh - alternatively referred to as the so-called Islamic State - enforced extremist governance over large swathes of Syria and Iraq until 2019.
"This strike shows British leadership, and commitment to operate in unison with allied nations, to stamp out any resurgence of IS and their harmful and extremist ideologies in the Middle East," Britain's Defence Chief the Defence Secretary remarked.
RAF aircraft have carried out surveillance missions over Syria to "prevent any attempted resurgence" of IS after its military defeat at the Baghuz confrontation in 2019, the ministry said.
"I must thank all the members of our armed forces who took part in this operation for their skill and their valour," the Defence Secretary commented. "They were among numerous UK service members deployed over the holidays. This action, to take out militants who endanger our security, shows how our armed forces are ready to step up, continuously, ensuring Britain's security at home and strong abroad."
In December, the US military executed what it described as a "massive strike" on IS targets in the country, following an attack killed two American soldiers and a local interpreter in the Palmyra area.
The United Nations estimates Daesh still maintains roughly 5-7 thousand fighters in Iraq and Syria.